Assessment of vascular invasion in gastric cancer: A comparative study

Table 4 Correlation of lymphatic and blood vessel invasion detected by immunohistochemistry with other prognostic factors (n = 95) n (%)

Data	LVI			BVI
	Negative	Positive	P value	Negative	Positive	P value
Tumor location
Distal third	15 (27.3)	40 (72.7)	0.0391	42 (76.3)	13 (23.7)	0.281
Other locations	14 (35.0)	26 (65.0)		29 (72.5)	11 (27.5)
Curvature
Small curvature	19 (35.2)	35 (64.8)	0.122	41 (76.0)	13 (24.0)	0.131
Large curvature	3 (30.0)	7 (70.0)		8 (80.0)	2 (20.0)
Small and large	1 (7.2)	13 (92.8)		7 (50.0)	7 (50.0)
Macroscopy
Borrmann I	5 (71.4)	2 (28.6)	0.0011	7 (100.0)	0 (0.0)	0.24
Borrmann II	4 (13.3)	26 (86.7)		21 (70.0)	9 (30.0)
Borrmann III	5 (18.5)	22 (81.5)		17 (62.9)	10 (37.1)
Borrmann IV	0 (0.0)	12 (100.0)		7 (58.3)	5 (41.7)
Organ invasion
Negative	26 (45.6)	31 (54.4)	0.0031	46 (80.7)	11 (19.3)	0.297
Duodenum	1 (4.3)	22 (95.7)		15 (65.2)	8 (34.8)
Esophagus	1 (12.5)	7 (87.5)		6 (75.0)	2 (25.0)
Both E + D	0 (0.0)	3 (100.0)		1 (33.3)	2 (66.7)
Other	1 (25.0)	3 (75.0)		3 (75.0)	1 (25.0)
Tumor depth
Early	17 (80.9)	4 (19.1)	0.0011	21 (100.0)	0 (0.0)	0.0031
Advanced	12 (16.2)	62 (83.8)		50 (67.5)	24 (32.5)
Laurén histology
Intestinal	12 (26.6)	33 (73.3)	0.228	36 (80.0)	9 (20.0)	0.332
Diffuse	11 (44.0)	14 (56.0)		19 (76.0)	6 (24.0)
Mixed/not classified	6 (24.0)	19 (76.0)		16 (64.0)	9 (36.0)

BVI: Blood vessel invasion; LVI: Lymphatic vessel invasion; E + D: Esophagus + duodenum.