XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians

Table 3 Xeroderma pigmentosum group C Lys939Gln polymorphism, smoking and colorectal cancer susceptibility risk

	Cases	Controls	OR (95%CI)	P-value
Genotype
Lys/Lys (AA)	108	129	1 (Reference)1
Lys/Gln (AC)	106	100	1.266 (0.871–1.841)	0.216
Gln/Gln (CC)	41	26	1.884 (1.082–3.277)	0.0252
Allele
A	322	358	1 (Reference)1	-
C	188	152	1.375 (1.050–1.802)	0.0202
Non-smoker
AA	64	104	1 (Reference)1
AC	64	81	1.284 (0.817–2.018)	0.278
CC	17	22	1.256 (0.620–2.542)	0.526
Smoker
AA	44	25	1 (Reference)1
AC	42	19	1.256 (0.605–2.609)	0.541
CC	24	4	3.409 (1.061–10.949)	0.0322

¹Homozygous wildtype genotype served as the reference category;

²Statistically significant.