Diagnostic value of endothelial markers and HHV-8 staining in gastrointestinal Kaposi sarcoma and its difference in endoscopic tumor staging

Table 2 Diagnostic value of endoscopic biopsy in gastrointestinal Kaposi sarcoma (n = 103)

KS/non-KS (84/19)	Sensitivity, % (95%CI)	Specificity, % (95%CI)	Positive LR (95%CI)	Negative LR (95%CI)	ROC area1 (95%CI)
HE	70.2 (59.3-79.7)	94.7 (74.0-99.9)	9.33 (1.99-43.8)2	0.32 (0.23-0.46)2	0.83 (0.75-0.90)
(59/1)
D2-40	77.4 (67.0-85.8)	100 (82.4-100)	30.8 (1.99-477)2	0.24 (0.16-0.35)2	0.89 (0.84-0.93)a
(65/0)
Blood vessel marker	81 (70.9- 88.7)	78.9 (54.4- 93.9)	3.85 (1.6-9.24)	0.24 (0.15-0.40)	0.80 (0.70-0.90)
(68/4)
HHV-8	63.1 (51.9-73.4)	100 (82.4-100)	25.2 (1.62-391)2	0.38 (0.29-0.51)2	0.82 (0.76-0.87)
(53/0)

LR: Likelihood ratio; HE: Hematoxylin and eosin; HHV: Human herpesvirus.

¹Receiver operating characteristic (ROC) area is significantly (P < 0.01) different in this category;

²LR estimated using the substitution formula. A value of 0.5 was added to all cell frequencies before calculation;

^aP < 0.05 for comparisons of lesions by HE staining.