Hepatoid adenocarcinoma of the extrahepatic duct

Figure 2 Histological and immunohistochemical features. A: Low-power microphotograph showing hepatoid areas (hematoxylin and eosin; original magnification, × 100); B, C: Hepatoid adenocarcinoma composed of cells with a clear cytoplasm arranged in a nested or trabecular pattern (hematoxylin and eosin; original magnification, × 400); D-H: Intracytoplasmic expression of hepatocyte paraffin 1, cytokeratin 8/18, polyclonal carcinoembryonic antigen and S-100 as well as Ki-67-positive nuclei (original magnification, × 400).