Effect of endogenous insulin-like growth factor and stem cell factor on diabetic colonic dysmotility

Figure 5 High glucose inhibited endogenous insulin-like growth factor-1 and stem cell factor expression. A: Expression of endogenous insulin-like growth factor-1 (IGF-1) in SMCs cultured in a high glucose (HG) medium for 24 h. ^bP < 0.01 vs the normal glucose (NG) group; B: Stem cell factor (SCF) expression in smooth muscle cells (SMCs) exposed to HG, and effects of the addition of exogenous IGF-1 (100 ng/mL). ^bP < 0.01 vs the NG group; and ^dP < 0.01 vs HG group. The Western blotting are representatives of 4 independent experiments. α-Tubulin was used as a loading control (each bar represents the mean ± SE of 3 independent experiments).