Sofosbuvir and ABT-450: Terminator of hepatitis C virus?

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Jun 7, 2013 (publication date) through Dec 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2013; 19(21): 3199-3206
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3199

Table 5 Interleukin-28B polymorphism in sofosbuvir and ABT-450 era

Group	Status before treatment	IL-28B CC (n)	IL-28B CT (n)	IL-28B TT (n)	SVR rate
Sofosbuvir
1	Untreated	5	4	1	100%
2	Untreated	4	4	1	100%
3	Untreated	4	4	2	100%
4	Untreated	4	5	2	100%
5	Untreated	2	6	2	60%
6	Untreated	3	6	1	100%
7	No response to prior therapy	2	5	3	10%
8	Untreated	11	12	2	84%
ABT-450
1	Untreated	10/9	7/7	2/2	95%
2	Untreated	5/4	7/7	2/2	93%
3	No or partial response to prior therapy	0/0	12/6	5/2	47%

IL-28B: Interleukin-28B; SVR: Sustained virologic response.

Citation: Zeng QL, Zhang JY, Zhang Z, Wang LF, Wang FS. Sofosbuvir and ABT-450: Terminator of hepatitis C virus? World J Gastroenterol 2013; 19(21): 3199-3206
URL: https://www.wjgnet.com/1007-9327/full/v19/i21/3199.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i21.3199