Neoadjuvant-intensified treatment for rectal cancer: Time to change?

Table 3 Incidence of acute toxicity n (%)

	G1	G2	G3
Blood-bone marrow
Neutrofilis-granulocytes	1 (1.25)
Allergy-immunology
Allergic reaction-hypersensitivity	6 (7.5)
Cardiac arrhythmia
Palpitation	1 (1.25)
Constitutional symptoms
Fatigue	10 (12.5)	5 (6.25)
Fever	7 (8.75)	1 (1.25)
Dermatology-skin
Pruritus-itching	2 (2.5)
Rash-desquamation	2 (2.5)	6 (7.5)
Radiation-dermatitis	10 (12.5)	17 (21.25)	3 (3.75)
Gastrointestinal
Constipation	2 (2.5)	15 (18.75)
Diarrhea	14 (17.5)	11 (13.75)	3 (3.75)
Nausea	12 (15)
Proctitis	6 (7.5)	51 (63.75)	4 (5)
Vomiting	5 (6.25)	1 (1.25)
Neurology
Neuropathy: sensory	14 (17.5)	1 (1.25)	1 (1.25)
Pain
Pelvic pain	1 (1.25)	3 (3.75)
Abdominal pain or cramping	6 (7.5)	2 (2.5)	2 (2.5)
Renal-genitourinary
Dysuria-painful urination	12 (15)	11 (13.75)
Urinary frequency	3 (3.75)
	G3	G4	G5
Cardiovascular
Vascular thromboembolism	7 (8.75)	2 (2.5)	2 (2.5)