MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults

doi:10.3748/wjg.v19.i20.3043

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2013; 19(20): 3043-3051
Published online May 28, 2013. doi: 10.3748/wjg.v19.i20.3043

Table 3 Relative MLH1 and MGMT mRNA expression levels

Subjects	MLH1		MGMT
	Methylated	Unmethylated	Methylated	Unmethylated
Chronic gastritis
Child H. pylori negative	-	0.25 ± 0.03	-	0.13 ± 0.08
Child H. pylori positive	-	0.27 ± 0.02	-	0.12 ± 0.01
Adults H. pylori negative	0.35 ± 0.01^b	0.85 ± 0.07	0.40 ± 0.16^b	0.99 ± 0.21
Adults H. pylori positive	0.88 ± 0.10^b	1.29 ± 0.27	0.79 ± 0.19^b	1.78 ± 0.47
Gastric cancer	0.27 ± 0.07	0.25 ± 0.08	0.49 ± 0.10	0.46 ± 0.10

MLH1 and MGMT mRNA values are expressed as the mean ± SD.

^bP < 0.01 vs unmethylated samples in the same subject category. H. pylori: Helicobacter pylori.

Citation: Alvarez MC, Santos JC, Maniezzo N, Ladeira MS, da Silva AL, Scaletsky IC, Pedrazzoli Jr J, Ribeiro ML. MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults. World J Gastroenterol 2013; 19(20): 3043-3051
URL: https://www.wjgnet.com/1007-9327/full/v19/i20/3043.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i20.3043