MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults

Table 2 Frequency of hypermethylation at the MLH1 and MGMT promoter regions in chronic gastritis and gastric cancer patients n (%)

Subjects	MLH1		MGMT
	Methylated	Unmethylated	Methylated	Unmethylated
Chronic gastritis
Child H. pylori negative	-	28 (100%)	-	28 (100%)
Child H. pylori positive	-	22 (100%)	-	22 (100%)
Adults H. pylori negative	1 (7%)	13 (93%)	3 (21%)	11 (79%)
Adults H. pylori positive	11 (13%)	72 (87%)	42 (51%)c	41 (49%)
Gastric cancer	36 (39%)ab	56 (61%)	61 (66%)de	31 (34%)

^aP < 0.05 vs Helicobacter pylori (H. pylori) negative;

^bP < 0.01 vs H. pylori positive chronic gastritis;

^cP < 0.05 vs H. pylori negative;

^eP < 0.05 vs H. pylori positive chronic gastritis and

^dP < 0.01 vs H. pylori negative chronic gastritis group.