Lubiprostone induced ischemic colitis

Figure 1 The laboratory studies results. A: Computed tomography scan shows thickening of the colonic wall involving the splenic flexure of the colon; B: Normal mucosa in the right colon (appendiceal orifice); C: Ischemic colitis features in the splenic flexure of the colon; D: Normal mucosa in sigmoid with a small polyp; E, F: Histopathology shows ischemic loss of crypts and acute hemorrhage in lamnia propria (acute hemorrhagic necrosis replacing glands) associated with acute fibrinopurulent exudate at colonic epithelial surface, consistent with ischemic colitis.