Inositol-requiring enzyme 1α is required for gut development in Xenopus lavies embryos

Figure 6 Injection of IRE1αΔC-GR mRNA caused morphological alterations with gut malformation. A: Diagram depicting the construction of deletion mutants. S and TM denote the signal peptide and the transmembrane domain; B-D: Gut defects were also observed with a dominant-negative mutant, IRE1αΔC, lacking the cytoplasmic kinase and RNase domains.