Intestinal injury can be reduced by intra-arterial postischemic perfusion with hypertonic saline

Figure 3 Area of necrosis within the isolated rat intestine after 60-min ischemia followed by the varying conditions of reperfusion. The area of necrosis (AN) is defined as the percentage of 2.3.5-triphenyltetrazolium chloride-negative in relation to the total intestinal tissue volume. Controls (reperfusion with normotonic saline) and the HTS^415mOsm group did not differ statistically regarding AN volume, whereas HTS^365mOsm administration resulted in a significantly lower value of AN. In both hypertonic saline (HTS) groups, the 5-min reperfusion with the appropriate hyperosmotic saline was followed by 25-min normotonic reperfusion. The data are presented as dot plots with median values.