Lubiprostone induced ischemic colitis

Table 2 Naranjo adverse drug reaction nomogram in our patient

	Yes	No	Our patient
Are there previous conclusive reports on this reaction?	1	0	0
Did the adverse event appear after the suspected drug was administered?	2	-1	2
Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?	1	0	1
Did the adverse reaction reappear when the drug was readministered?	2	-1	2
Are there alternative causes (other than the drug) that could have, on their own, caused the reaction?	-1	2	2
Did the reaction appear when a placebo was given?	-1	1	1
Was the drug detected in the blood (or other fluids) in concentration known to be toxic?	1	0	0
Was the reaction more severe when the dose was increased or less severe when dose was decreased?	1	0	0
Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	1	0	1
Was the adverse event confirmed by any objective evidence?	1	0	1
			10

Definite: score ≥ 9; Probable: 5-8; Possible: 1-4; Doubtful: ≤ 0.