IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients

doi:10.3748/wjg.v19.i2.290

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Jan 14, 2013 (publication date) through Jan 30, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2013; 19(2): 290-298
Published online Jan 14, 2013. doi: 10.3748/wjg.v19.i2.290

Table 1 Statistical analyses of the different IL28B genotypes and alleles in non-responder and sustained viral response patients n (%)

	Non-responders (NR = 79)	Responders (SVR = 87)	Odds ratio	95%CI	P value
CC (n = 24)	8 (33.3)	16 (66.7)	4.575	1.376-7.846	0.025
CT (n = 117)	58 (49.6)	59 (50.4)	0.858	0.538-1.449	0.589
TT (n = 25)	13 (52)	12 (48)	0.978	0.758-1.759	0.464
C (n = 165)	74 (44.8)	91 (55.2)	1.636	0.773-3.465	0.198
T (n = 167)	84 (50.3)	83 (49.7)	0.798	0.598-1.349	0.604

Frequencies of genotypes and alleles at IL28B SNP were compared between SVR and NR patients. Genotype CC were associated with SVR (P = 0.025). SVR: Sustained viral response; NR: Non-responder.

Citation: El Awady MK, Bader El Din NG, Tabll A, El Hosary Y, Abdel Aziz AO, El Khayat H, Salama M, Abdelhafez TH. IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients. World J Gastroenterol 2013; 19(2): 290-298
URL: https://www.wjgnet.com/1007-9327/full/v19/i2/290.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i2.290