Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation

Figure 5 Liver sections were stained with heme oxygenase-1 antibody. A: Heme oxygenase-1 (HO-1) expression was less around the central veins in the Sham group; B, C, E: Much more HO-1 expression was found around the central veins in the bile duct ligation (BDL) group, cobalt protoporphyrin (CoPP) group and Fe group; D, F: Less staining was observed in the zinc protoporphyrin (ZnPP) group and deferoxamine (DFX) group; H: Immunohistochemical staining scores (magnification ×400). Values are expressed as mean ± SE (n = 6). ^bP < 0.01 vs Sham group; ^cP < 0.05, ^dP < 0.01 vs BDL group; ^fP < 0.01 vs ZnPP group.