Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation

Figure 1 Pathological features of rat liver tissue detected by hematoxylin and eosin staining and serum index. A: Normal lobular architecture in the Sham group; B, C, E: Obvious fibrous hyperplasia and fibrosis extension with fibroblast proliferation in the bile duct ligation (BDL) group, cobalt protoporphyrin (CoPP) group and Fe group; D and F: Less fibrous hyperplasia and fibrosis in the zinc protoporphyrin (ZnPP) group and deferoxamine (DFX) group; G, H: Levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBIL); I: Histopathological scores for fibrosis (magnification × 100). Values are expressed as mean ± SE (n = 6). ^bP < 0.01 vs Sham group; ^cP < 0.05, ^dP < 0.01 vs BDL group; ^fP < 0.01 vs ZnPP group.