Overexpression of p42.3 promotes cell growth and tumorigenicity in hepatocellular carcinoma

Figure 3 Promotion of cell growth and colony formation with p42. 3 overexpression in HepG2 cells. A: Promotion of cell growth after overexpression of p42.3 in HepG2. Growth curve comparing HepG2-p42.3-1, HepG2-p42.3-2, and HepG2-vector cells over a 6-d time course. Data are shown as the mean ± SD of three independent experiments (^bP < 0.01 vs HepG2-p42.3-1); B: The colonies of HepG2-p42.3-1, HepG2-p42.3-2, and HepG2-vector formed on soft agar. The colonies grew faster and were larger in HepG2 cells that overexpressed p42.3-2 than in the HepG2-vector control cells; C: Raw value indicating colony number. Data revealed that the colony-forming activities of HepG2-p42.3-1 and HepG2-p42.3-2 were significantly promoted on soft agar. The data represent the mean ± SD of three independent experiments (^bP < 0.01 vs HepG2-vector).