Predominant mucosal IL-8 mRNA expression in non-cagA Thais is risk for gastric cancer

Table 2 Serum enzyme pepsinogen I, II level and Helicobacter pylori infection detection results in Thais n (%)

Variable	Cancer (n = 86)	Benign (n = 134)	P value
PG I/II, (ng/μL), mean ± SD
I	57.39 ± 46	54.86 ± 68.5	0.780
II	19.42 ± 21	15.42 ± 11.7	0.090
PG I/II ratio
≤ 3	28 (39.4)	34 (27.9)	0.0451
> 3	43 (60.6)	88 (70.1)
H. pylori pathology
Negative	31 (36.8)	60 (44.8)	0.001
Positive	55 (63.2)	74 (55.2)
Serum IgG
Negative	31 (46.3)	57 (44.2)	0.8201
Positive	36 (53.7)	72 (55.8)
CagA genotyping in positive 23S rDNA
Negative	55 (88.7)	62 (64.6)	< 0.0011
Positive	7 (12.3)	34 (35.4)
H. pylori Infection status
True negative	20 (24.4)	37 (36.0)	0.1201
True positive	62 (75.6)	96 (64.0)

¹Some numbers are not included in the analysis due to missing laboratories entries. The statistical analysis was performed by χ² of each factor. IgG: Immunoglobulin G; CagA: Cytotoxin-associated gene A; PG: Pepsinogen; H. pylori: Helicobacter pylori.