MAWBP and MAWD inhibit proliferation and invasion in gastric cancer

Figure 4 Effect of mitogen-activated protein kinase activator with WD40 repeats binding protein and mitogen-activated protein kinase activator with WD40 repeats on invasive ability of gastric cancer cells. A: Transwell assay showed that invasive ability of mitogen-activated protein kinase activator (MAWD) with WD40 repeats binding protein (MAWBP)/D cotransfected cells was weakest, with the lowest number of cells to cross the matrix membranes. Vector-transfected cells migrated farthest; B: Knockdown of MAWBP and MAWD increased the invasive ability of gastric cancer (GC) cells (original magnification: ×100); C: Number of cells that traverse the matrix membrane in the different groups. Data are presented as the mean ± SD from three independent experiments. ^bP < 0.01 vs vector group.