Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats

Figure 2 Effect of α-lipoic acid on portal endotoxemia-induced changes in hepatic oxidative and inflammatory markers. The following parameters were measured from liver of each group of fructose-fed rats and the control group: (A) Malondialdehyde (MDA) content; (B) Glutathione (GSH) content; (C) Toll-like receptor 4 (TLR4) gene expression; (D) Tumor necrosis factor alpha (TNF-α) protein; and (E) Interleukin-6 (IL-6) protein. Values are expressed as mean ± SE, n = 6 per group. ^aP < 0.05 vs C_PV; ^cP < 0.05 vs F_PV; ^eP < 0.05 vs F_PLPS. C: Regular diet; F: High-fructose enriched diet; LA: Lipoic acid; LPS: Lipopolysaccharides.