Prognostic value of preoperative mean corpuscular volume in esophageal squamous cell carcinoma

Table 2 Univariate and multivariate Cox regression analysis for overall survival

Factors	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value1	HR (95%CI)	P value1
Age, yr	1.007 (0.985-1.029)	0.527
Gender (male vs female)	0.744 (0.464-1.196)	0.222
Smoking index ( ≤ 400 vs > 400)	1.391 (0.940-2.060)	0.099	1.302 (0.874-1.940)	0.194
BMI, kg/m2 ( ≤ 20 vs > 20; ≤ 25 vs > 25)	0.878 (0.638-1.207)	0.422
Preoperative MCV, fl ( ≤ 95.6 vs > 95.6)	2.495 (1.644-3.787)	< 0.001	2.108 (1.372-3.241)	0.001
Preoperative RBC, × 1012/L ( ≤ 4 vs > 4)	0.685 (0.433-1.082)	0.105	0.835 (0.507-1.350)	0.462
Preoperative albumin, g/L	0.954 (0.919-0.990)	0.012	0.938 (0.900-0.977)	0.002
pT status (pT1 vs pT2 and pT3)	1.641 (1.147-2.348)	0.007	1.589 (1.084-2.327)	0.018
pN status (pN0 vs pN1, pN2 and pN3)	1.954 (1.603-2.382)	< 0.001	1.957 (1.602-2.392)	< 0.001
Histologic grade (G1 vs G2 and G3)	0.961 (0.714-1.293)	0.791
Tumor location (upper thoracic vs middle thoracic and lower thoracic)	0.798 (0.605-1.051)	0.109	0.692 (0.522-0.916)	0.01

¹Cox proportional hazards model. HR: Hazard ratio; BMI: Body mass index; MCV: Mean corpuscular volume; RBC: Red blood cell.