Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis

Figure 6 Statistical evaluation of interleukin-22 and its related proteins in human colonic biopsy specimens from patients with inactive ulcerative colitis, active ulcerative colitis, and ulcerative colitis with dysplasia. The average integrated optical density (IOD) for immunohistochemistry staining of interleukin (IL)-22 (A), IL-23 (B), IL-22R1 (C), and p-STAT3 (S727) (D) in colonic tissues with ulcerative colitis (UC) and UC-related carcinogenesis (UC-CRC). Significantly higher expression levels of IL-22, IL-23, IL-22R1, and p-STAT3 were observed in the dysplasia group, as compared with the inactive and active UC groups.