Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis

Figure 4 Statistical evaluation of interleukin-22 and its related proteins in human colonic biopsy specimens from controls and patients with chronic and initial ulcerative colitis. The average integrated optical density (IOD) for the immunohistochemistry staining of interleukin (IL)-22 (A), IL-23 (B), IL-22R1 (C), and p-STAT3 (S727) (D) in colonic tissues with initial and chronic ulcerative colitis (UC). Significantly higher expression levels of IL-22 and IL-22R1 were observed in the initial UC group as compared with the chronic UC group. p-STAT3 was highly expressed in the chronic UC group.