Dietary polyphenols and colorectal cancer risk: The Fukuoka colorectal cancer study

Table 4 Association of frequency of coffee consumption with colorectal cancer risk

	Frequency of coffee consumption					Ptrend
	< 1 cup/wk	1-3 cups/wk	4-6 cups/wk	1-3 cups/d	≥4 cups/d
Colorectal
Cases/controls	245/181	93/83	66/78	265/317	147/156
OR (95%CI)1	1 (reference)	0.88 (0.61, 1.26)	0.66 (0.45, 0.99)	0.65 (0.50, 0.85)	0.82 (0.59, 1.13)	0.01
Colon
Cases/controls	145/181	62/83	40/78	141/317	75/156
OR (95%CI)1	1 (reference)	1.04 (0.69, 1.57)	0.75 (0.47, 1.18)	0.64 (0.47, 0.87)	0.78 (0.53, 1.14)	0.01
Proximal colon
Cases/controls	60/181	22/83	19/78	62/317	25/156
OR (95%CI)1	1 (reference)	0.84 (0.47, 1.50)	0.88 (0.48, 1.62)	0.69 (0.45, 1.06)	0.69 (0.39, 1.21)	0.08
Distal colon
Cases/controls	84/181	40/83	21/78	78/317	49/156
OR (95%CI)1	1 (reference)	1.16 (0.72, 1.89)	0.65 (0.37, 1.15)	0.58 (0.40, 0.85)	0.82 (0.52, 1.29)	0.02
Rectum
Cases/controls	98/181	29/83	26/78	118/317	69/156
OR (95%CI)1	1 (reference)	0.63 (0.38, 1.04)	0.55 (0.32, 0.93)	0.63 (0.45, 0. 88)	0.82 (0.54, 1.23)	0.10

¹Adjusted for age, sex, residence area, parental history of colorectal cancer, smoking, alcohol drinking, body mass index 10 years before, type of job, leisure-time physical activity, calcium and n-3 polyunsaturated fatty acid. OR: Odds ratio.