Emodin regulating excision repair cross-complementation group 1 through fibroblast growth factor receptor 2 signaling

Figure 2 DNA damage detected by single cell gel electrophoresis in HepG2. A-D: Ethidium bromide stain (magnification × 200). Control group (A); Oxaliplatin (OXA) group (B); OXA + fibroblast growth factor 7 (FGF7) group (C); OXA + emodin group (D); E: The tail extent (TE), the Olive tail moment (OTM) and the percentage of tail DNA (PTD) were considerably increased in the OXA + emodin group in comparison with the OXA group and the OXA + FGF7 group, respectively, and these differences were statistically significant. TE, OTM and PTD were significantly lower in the OXA + FGF7 group compared with OXA + emodin group and OXA group; however, these values were higher than those of the control group (^aP < 0.05, ^bP < 0.01 vs control group; ^cP < 0.05, ^dP < 0.01 vs OXA group; ^fP < 0.01 vs OXA + FGF7 group).