Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis

doi:10.3748/wjg.v19.i16.2543

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2013; 19(16): 2543-2549
Published online Apr 28, 2013. doi: 10.3748/wjg.v19.i16.2543

Table 1 Baseline characteristics of the patients n (%)

Characteristics	Total (n = 412)	Severe hepatitis (n = 92)	Non-severe hepatitis (n = 320)	P value	Prolonged cholestasis(n = 21)	Non-prolonged cholestasis (n = 391)	P value
Age¹ (yr)	34.4 ± 11.4	36.5 ± 11.5	33.8 ± 11.4	0.035	42.6 ± 15.0	34.0 ± 11.1	0.013
Gender, male	237 (57.5)	62 (67.4)	175 (54.7)	0.032	11 (52.4)	226 (57.8)	0.655
Etiology
Hepatitis A	319 (77.4)	67 (72.8)	252 (78.8)		8 (38.1)	311 (79.5)
Toxic	44 (10.7)	17 (18.5)	27 (8.4)		10 (47.6)	34 (8.7)
Unknown	25 (6.1)	1 (1.1)	24 (7.5)		0 (0)	25 (6.4)
Hepatitis B	16 (3.9)	4 (4.3)	12 (3.8)		2 (9.5)	14 (3.6)
Alcohol	4 (1.0)	1 (1.1)	3 (0.9)		0 (0)	4 (1.0)
Hepatitis C	2 (0.5)	1 (1.1)	1 (0.3)		1 (4.8)	1 (0.3)
Autoimmune	2 (0.5)	1 (1.1)	1 (0.3)		0 (0)	2 (0.5)
Etiology, toxic	44 (10.7)	17 (18.5)	27 (8.4)	0.001	10 (47.6)	34 (8.7)	< 0.001
ALT¹ (IU/L)	2053 ± 1759	2145 ± 2207	2027 ± 1611	0.392	998 ± 1090	2110 ± 1772	0.001
ALP¹ (IU/mL)	155 ± 75	152 ± 72	156 ± 76	0.983	153 ± 110	156 ± 73	0.265
Bilirubin¹ (mg/dL)	5.6 ± 4.9	11.2 ± 6.7	3.9 ± 2.6	< 0.001	18.6 ± 6.9	4.9 ± 3.7	< 0.001
Albumin¹ (g/dL)	3.9 ± 0.4	3.8 ± 0.4	4.0 ± 0.4	< 0.001	3.8 ± 0.4	3.9 ± 0.4	0.174
PT¹ (%)	81.0 ± 18.0	75.2 ± 22.7	83.7 ± 16.6	0.003	84.6 ± 15.0	81.7 ± 18.6	0.721
GWT¹, mm	5.2 ± 5.5	7.2 ± 6.0	5.5 ± 5.3	0.009	9.6 ± 6.7	5.7 ± 5.4	0.003
> 3	233 (56.5)	70 (70.7)	168 (51.7)	0.004	17 (81.0)	216 (55.2)	0.025
> 7	142 (34.5)	36 (39.1)	106 (33.1)	0.040	11 (52.4)	131 (33.5)	0.005
Arterial heterogeneity (+)	294 (80.1)	68 (73.9)	226 (70.6)	0.755	15 (71.5)	279 (71.3)	1.000
Periportal tracking (+)	348 (84.7)	78 (84.8)	270 (84.4)	0.869	18 (85.7)	330 (84.4)	1.000
LN number¹	4.8 ± 3.0	5.1 ± 3.3	4.8 ± 2.9	0.581	5.3 ± 3.7	4.8 ± 3.0	0.701
LN size¹ (cm)	0.97 ± 0.26	0.99 ± 0.28	0.96 ± 0.26	0.465	0.97 ± 0.30	0.97 ± 0.26	0.743
≥ 0.8	346 (84.5)	79 (85.9)	267 (83.4)	0.632	17 (81.0)	329 (84.1)	0.759
> 1	162 (39.3)	42 (45.7)	120 (37.5)	0.183	10 (47.6)	152 (38.9)	0.494
Ascites (+)	56 (13.6)	17 (18.5)	39 (12.2)	0.123	7 (33.3)	49 (12.5)	0.015
Spleen size¹ (cm)	10.9 ± 1.6	11.04 ± 1.68	10.84 ± 1.60	0.419	10.44 ± 1.7	10.91 ± 1.6	0.094
≥ 12	95 (23.1)	24 (26.1)	71 (22.2)	0.483	3 (14.3)	92 (23.5)	0.431

¹Data presented as mean ± SD. ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; PT: Prothrombin time; GWT: Gallbladder wall thickness; LN: Lymph node.

Citation: Park SJ, Kim JD, Seo YS, Park BJ, Kim MJ, Um SH, Kim CH, Yim HJ, Baik SK, Jung JY, Keum B, Jeen YT, Lee HS, Chun HJ, Kim CD, Ryu HS. Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis. World J Gastroenterol 2013; 19(16): 2543-2549
URL: https://www.wjgnet.com/1007-9327/full/v19/i16/2543.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i16.2543