Overexpression of carbonic anhydrase II and Ki-67 proteins in prognosis of gastrointestinal stromal tumors

Table 2 Multivariate survival analysis (Cox proportional hazards model) in gastrointestinal stromal tumors

Variable	B	Wald	df	P value	HR	95%CI for HR
						Lower	Upper
Age	0.023	1.696	1	0.193	1.024	0.988	1.060
Sex	-0.239	0.342	1	0.559	0.788	0.354	1.754
Mucosal erosion or not	1.485	2.115	1	0.146	4.416	0.597	32.684
Biopsy or not	-0.404	0.901	1	0.340	0.668	0.291	1.531
CD34	-0.071	0.086	1	0.769	0.932	0.582	1.493
CA II	-0.319	4.113	1	0.043	0.727	0.543	0.989
CD117	-0.609	4.114	1	0.042	0.544	0.303	0.978
Ki-67	1.103	7.282	1	0.007	3.014	1.352	6.717
Diameter	1.645	4.974	1	0.026	5.182	1.216	22.085
Mitotic rate	0.972	11.081	1	0.001	2.644	1.491	4.686
Site	1.334	15.581	1	0.000	3.796	1.955	7.371
Depth of invasion	0.559	7.445	1	0.006	1.748	1.170	2.612
Complete resection or not	2.807	24.674	1	0.000	16.555	5.470	50.104
Intraoperative rupture	1.937	17.997	1	0.000	0.144	0.059	0.353
Adjuvant therapy	1.757	35.579	1	0.000	5.796	3.254	10.325

This table shows that carbonic anhydrase (CA) II, CD117 and Ki-67 expression, tumor diameter, mitotic rate, tumor site, depth of invasion, complete resection, intraoperative rupture, and adjuvant therapy were important prognosis predictive factors. HR: Hazard ratios.