Genetic association of interleukin-6 polymorphism (-174 G/C) with chronic liver diseases and hepatocellular carcinoma

Table 3 Studies examining the role of interleukin-6 polymorphism (-174 G/C) in hepatocellular carcinoma

Ref.	Country	Ethnicity	Cases	Controls	Genotyping method	Association with HCC
Nieters et al[65]	China	Asian	250	250	PCR-RFLP	NS
Ognjanovic et al[66]	United States	American1	120	230	5’nuclease Taqman allelic discrimination assay	Positive significant
Falleti et al[67]	Italy	Caucasian	219	-	PCR-RFLP	Positive significant
Giannitrapani et al[15]	Italy	Caucasian	105	-	PCR-RFLP	Positive significant

¹White, black and hispanic. PCR-RFLP: Polymerase chain reaction - restriction fragment length polymorphism; HCC: Hepatocellular carcinoma; NS: Not significant.