Genetic association of interleukin-6 polymorphism (-174 G/C) with chronic liver diseases and hepatocellular carcinoma

Table 1 Studies examining the role of interleukin-6 polymorphism (-174 G/C) in hepatitis C virus and hepatitis B virus infection

Ref.	Country	Ethnicity	Cases	Controls	Genotyping method	Association with chronic hepatitis/response to therapy
Barrett et al[20]	Ireland	Caucasian	158	-	PCR-SSP	Positive significant/-
Nattermann et al[23]	Germany	Caucasian	210	100	Cytokine genotyping tray	-/Uncertain
Falleti et al[25]	Italy	Caucasian	121	-	PCR-RFLP	Positive significant /-
Park et al[26]	South Korea	Asian	1046	-	PCR-SBE	NS/-
Ribeiro et al[27]	Brazil	American1	26	41	PCR-SSP	NS/-

¹White, black and hispanic. PCR-SSP: Polymerase chain reaction - single specific primer; PCR-RFLP: Polymerase chain reaction - restriction fragment length polymorphism; PCR-SBE: Polymerase chain reaction - single base primer extension assay; NS: Not significant.