Depletion of telomerase RNA inhibits growth of gastrointestinal tumors transplanted in mice

Figure 2 Phosphorothioate antisense oligodeoxynucleotides mediated inhibition of tumor growth in human gastrointestinal stromal tumors (n = 10 tumors per group). Daily intra-tumor injection of phosphorothioate antisense oligodeoxynucleotides (PS-ASODN) and other reagents commenced on post-inoculation day 7 and continued to day 28. A: Tumor volume; B: Tumor weight; C: Inhibition of tumor growth. ^bP < 0.01 vs liposome negative control and imatinib groups. Each bar represents the mean ± SD.