Clinical application of microRNA in gastric cancer in Eastern Asian area

Table 2 Expression of miRNA and area under curve, sensitivity and specificity in serum samples of patients with gastric cancer

Group	Sample	MicroRNA	AUC	Method	Sensitivity/specificity (%)
Liu et al[49]	61 GC/61 C	miR-378↑	0.861	qRT-PCR	87.5/70.7
Liu et al[50]	164 GC/127 C	(miR-1, miR-20a, miR-27a, miR-34, miR-423-5P)↑	0.879	Microarray + qRT-PCR	79.3/86.5
			0.831
Konish et al[51]	56 GC/30 C	miR-451↑	0.96	Microarray + qRT-PCR	96.0/100
		miR-486↑	0.92		86.0/97.0
Song et al[52]	82 GC/82 C	miR-221, miR-744 and miR-376c↑	NA	qRT-PCR	82.4/58.8
Zhou et al[53]	90 GC/27 C	miR-106a↑	0.684	Microarray + qRT-PCR	48.2/90.2
		miR-17↑	0.743		51.9/92.7
Wang et al[54]	174 GC/39 C	miR-21↑	0.81	Microarray + qRT-PCR	56.7/94.9
Tsujiura et al[55]	69 GC/30 C	miR-106b↑	0.72	Microarray + qRT-PCR	NA
		miR-106a↑, let-7a↓	0.879		85.5/80.0

qRT-PCR: Quantitative reverse transcriptase polymerase chain reaction; GC: Gastric cancer, C: Control; AUC: Area under curve; NA: Not available; ↑: Upregulated; ↓: Downregulated.