Role of T cell death in maintaining immune tolerance during persistent viral hepatitis

Figure 7 Balance between co-stimulatory/apoptotic molecules and viral-specific cytotoxic T lymphocytes reactivity according to infection outcome. Neg.: Negative; Pos.: Positive; CTLs: Cytotoxic T lymphocytes; (+): Possible molecules induced by viral infection; (-): Possible molecules down-regulated by viral infection; BIM: Bcl-2 interacting mediator; Mcl-1: Myeloid cell leukemia sequence-1.