Role of T cell death in maintaining immune tolerance during persistent viral hepatitis

Figure 1 Collective illustration of the hepatic cells with inflammatory and tolerance activities by stimulation of different molecules or receptors. LSEC: Liver sinusoidal endothelial cells; KC: Kuffer cells; DC: Dendritic cells; HSC: Hepatic stellate cells; TNF: Tumor necrosis factor; IL: Interleukin; mDC: Myeloid dendratic cell; pDC: Plasmacytoid dendritic cell; PD-L1: Programmed death ligand-1; Bim: BCL-2 interacting mediator; Tim-3: T cell immunoglobulin mucin-3; CTLA-4: Cytotoxic T-lymphocyte antigen 4; TGF: Transforming growth factor; NO: Nitric oxide.