Clinical application of liver stiffness measurement using transient elastography in chronic liver disease from longitudinal perspectives

Table 1 Diagnostic performance of transient elastography for prediction of esophageal varices or large esophageal varices

Ref.	No. of patients (etiology)	Endpoints	AUROC	Cutoffs (kPa)	Sensitivity	Specificity	PPV	NPV
Vizzutti et al[33]	47 (HCV)	EV	0.76	17.6	90%	43%	77%	66%
Castéra et al[38]	70 (HCV)	EV	0.84	21.5	76%	78%	68%	84%
		Large EV	0.87	30.5	77%	85%	56%	94%
Kazemi et al[40]	165 (CLD)	EV	0.83	13.9	95%	43%	57%	91%
		Large EV	0.84	19.0	91%	60%	48%	95%
Bureau et al[41]	89 (CLD)	EV	0.85	21.1	84%	71%	NA	NA
		Large EV	0.76	29.3	81%	61%	NA	NA
Pritchett et al[42]	211 (CLD)	EV	0.74	19.5	76%	66%	56%	82%
		Large EV	0.76	19.8	91%	56%	91%	55%
Nguyen-Khac et al[43]	183 (CLD)	Large EV	0.76	48.0	73%	73%	44%	90%
	58 (HCV/HBV)	Large EV	0.73	19.8	89%	55%	27%	97%
	103 (alcohol)	Large EV	0.77	47.2	85%	64%	44%	93%
Malik et al[44]	124 (CLD)	EV	0.85	20.0	NA	NA	80%	75%

AUROC: Area under the receiver operating characteristic curve; PPV: Positive predictive value; NPV: Negative predictive value; CLD: Chronic liver disease; EV: Esophageal varix; HCV: Hepatitis C virus; HBV: Hepatitis B virus; NA: Not available.