Molecular mechanisms of liver ischemia reperfusion injury: Insights from transgenic knockout models

Figure 1 Schematic diagram of cellular mechanisms of liver ischaemia reperfusion injury within a liver sinusoid and the surrounding area containing hepatocytes. Initial sinusoidal perfusion failure from platelet plugging, then Kupffer cells activate CD4+ T cells that activate natural killer T (NKT) cell which cause sinusoidal endothelial cells (SEC) and hepatocyte injury, followed by neutrophil activation, adhesion and transmigration causing more cell injury.