Psychosocial factors and their association with reflux oesophagitis, Barrett’s oesophagus and oesophageal adenocarcinoma

Table 2 Self-reported stress levels during lifetime

	Controls	RO		BO		OAC
Stress levels	n (%)	n (%)	AOR (95%CI)	n (%)	AOR (95%CI)	n (%)	AOR (95%CI)
Reed stress inventory levels
Low	45 (17.6)	63 (27.9)	1.00	60 (27.2)	1.00	81 (36.3)	1.00
Medium	154 (60.2)	122 (54.0)	0.92 (0.51-1.63)	102 (46.2)	0.51 (0.31-0.86)	91 (40.8)	0.37 (0.23-0.61)
High	57 (22.3)	41 (18.1)	1.43 (0.64-3.22)	59 (26.7)	0.60 (0.33-1.09)	51 (22.9)	0.51 (0.29-0.90)
			P for trend 0.48		P for trend 0.10		P for trend 0.010
Teenage years
1	135 (52.7)	132 (58.7)	1.00	122 (55.5)	1.00	127 (57.5)	1.00
2	67 (26.1)	53 (23.6)	1.05 (0.64-1.71)	42 (19.1)	0.73 (0.43-1.23)	32 (14.5)	0.63 (0.37-1.06)
3	31 (14.1)	26 (11.6)	0.77 (0.40-1.49)	31 (14.1)	1.06 (0.57-1.96)	42 (19.0)	1.50 (0.84-2.67)
4	16 (6.3)	11 (4.9)	0.67 (0.26-1.70)	14 (6.4)	0.75 (0.31-1.79)	9 (4.1)	0.58 (0.23-1.48)
5	7 (2.7)	3 (1.3)	0.28 (0.06-1.26)	11 (5.0)	0.76 (0.25-2.29)	11 (5.0)	1.18 (0.40-3.48)
			P for trend 0.10		P for trend 0.55		P for trend 0.85
Young adulthood
1	64 (25.0)	38 (16.9)	1.00	76 (34.7)	1.00	70 (32.3)	1.00
2	67 (26.2)	61 (27.1)	2.04 (1.11-3.76)	47 (21.5)	0.59 (0.34-1.04)	52 (24.0)	0.80 (0.47-1.38)
3	82 (32.0)	75 (33.3)	1.92 (1.06-3.49)	57 (26.0)	0.47 (0.27-0.81)	55 (25.4)	0.67 (0.39-1.14)
4	32 (12.5)	39 (17.3)	2.65 (1.27-5.55)	23 (10.5)	0.46 (0.22-0.96)	24 (11.1)	0.71 (0.35-1.44)
5	11 (4.3)	12 (5.3)	3.20 (1.07-9.55)	16 (7.3)	0.86 (0.33-2.28)	16 (7.4)	1.22 (0.47-3.18)
			P for trend 0.01		P for trend 0.05		P for trend 0.49
Midlife
1	68 (28.7)	20 (9.1)	1.00	52 (25.0)	1.00	58 (27.9)	1.00
2	57 (24.1)	38 (17.2)	2.56 (1.22-5.37)	39 (18.8)	0.87 (0.48-1.59)	62 (29.8)	1.25 (0.73-2.16)
3	55 (23.2)	50 (22.6)	4.04 (1.97-8.25)	48 (23.1)	1.07 (0.59-1.94)	38 (18.3)	0.95 (0.53-1.71)
4	41 (17.3)	76 (34.4)	8.50 (4.14-17.46)	47 (22.6)	1.23 (0.65-2.30)	25 (12.0)	0.70 (0.36-1.36)
5	16 (6.8)	37 (16.7)	9.82 (4.11-23.45)	22 (10.6)	1.27 (0.55-2.89)	25 (12.0)	1.60 (0.72-3.53)
			P for trend 0.001		P for trend 0.33		P for trend 0.97
Senior years
1	64 (42.4)	30 (24.4)	1.00	47 (39.2)	1.00	47 (37.3)	1.00
2	38 (25.1)	28 (22.8)	1.76 (0.86-3.61)	23 (19.2)	0.71 (0.35-1.45)	32 (25.4)	1.08 (0.56-2.09)
3	30 (19.9)	22 (17.9)	1.77 (0.82-3.83)	22 (18.3)	0.93 (0.44-1.96)	19 (15.1)	0.84 (0.40-1.78)
4	12 (8.0)	23 (18.7)	4.28 (1.72-10.67)	18 (15.0)	2.15 (0.85-5.43)	14 (11.1)	1.71 (0.67-4.35)
5	7 (4.6)	20 (16.3)	5.92 (1.72-16.77)	10 (8.3)	1.48 (0.48-4.54)	14 (11.1)	2.35 (0.82-6.70)
			P for trend 0.001		P for trend 0.20		P for trend 0.14

RO: Reflux oesophagitis; BO: Barrett’s oesophagus; OAC: Oesophageal adenocarcinoma; 1: Low; 2-4: Medium; 5: High; AOR: Adjusted odds ratio.