Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids

doi:10.3748/wjg.v19.i11.1718

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Mar 21, 2013; 19(11): 1718-1727
Published online Mar 21, 2013. doi: 10.3748/wjg.v19.i11.1718

Table 1 CpG islands hypermethylation of tumor-associated genes in pancreatic fluids

	Age (yr)	Sex	Stage	UCHL1	RUNX3	CDKN2A	IGF2	CACNA1G	AHRR	SFRP1	MGMT	APC	NEUROG1
NC1	68	M		MN	MN	MN	MN	MN	MN	MP	MP	MN	MN
NC2	65	M		MN	MN	MN	MN	MP	MN	MN	MN	MN	MN
NC3	59	M		MN	MN	MP	MN	MN	MN	MN	MN	MN	MP
NC4	70	F		MN	MN	MN	MP	MN	MN	MN	MN	MN	MN
NC5	43	F		MN	MN	MN	MN	MN	MN	MN	MP	MN	MN
NC6	55	M		MN	MN	MN	MN	MP	MN	MN	MN	MN	MN
NC7	49	M		MN	MN	MN	MN	MN	MP	MN	MN	MP	MN
				MN	MN	MN	MN	MN	MN	MN	MN	MN	MN
IP1	71	F		MN	MN	MP	MN	MN	MN	MN	MN	MN	MN
IP2	79	F		MN	MN	MN	MN	MN	MN	MN	MN	MN	MP
IP3	76	M		MN	MP	MN	MN	MN	MN	MN	MP	MN	MN
IP4	75	F		MN	MN	MN	MP	MN	MP	MP	MN	MP	MN
IP5	84	F		MN	MN	MN	MN	MN	MN	MP	MN	MN	MN
IP6	52	M		MN	MN	MP	MN	MN	MN	MP	MP	MN	MN
IP7	62	M		MN	MN	MN	MP	MN	MN	MN	MP	MP	MN
IP8	63	M		MN	MN	MP	MN	MN	MN	MN	MP	MN	MN
				MN	MN	MN	MN	MN	MN	MN	MN	MN	MN
PC1	66	F	IIA	MP	MN	MN	MN	MN	MN	MN	MP	MN	MN
PC2	54	F	III	MN	MP	MN	MN	MN	MN	MN	MN	MN	MN
PC3	66	M	IIB	MP	MP	MN	MN	MN	MN	MP	MN	MP	MP
PC4	67	M	IIB	MP	MN	MN	MN	MP	MN	MN	MN	MP	MN
PC5	71	M	IIB	MN	MP	MP	MN	MN	MN	MN	MN	MN	MN
PC6	49	F	IIA	MP	MP	MN	MN	MN	MN	MP	MN	MP	MP
PC7	73	F	IIB	MP	MN	MN	MN	MN	MP	MP	MN	MN	MN
PC8	75	M	III	MP	MP	MN	MN	MN	MN	MN	MN	MP	MN
PC9	59	M	IIB	MN	MN	MN	MN	MP	MN	MP	MP	MP	MP
PC10	78	F	IIA	MP	MP	MP	MN	MN	MN	MP	MP	MN	MP
PC11	75	F	IIB	MN	MN	MN	MP	MN	MN	MP	MN	MN	MN
PC12	66	M	IV	MP	MP	MP	MN	MN	MN	MP	MN	MP	MP
PC13	70	F	IV	MP	MN	MN	MN	MN	MP	MP	MP	MP	MP
PC14	68	M	IB	MN	MP	MN	MN	MN	MN	MN	MP	MN	MN
PC15	62	M	IIB	MP	MN	MP	MN	MN	MN	MN	MN	MN	MN

NC: Non-cancer; IP: Intraductal papillary and mucinous pancreatic tumour; pancreatic cancer (PC) 1, PC5, PC7, PC8 and PC13 are identical in Tables 1 and 2. MP: Methylation-positive; MN: Methylation-negative.

Citation: Kato N, Yamamoto H, Adachi Y, Ohashi H, Taniguchi H, Suzuki H, Nakazawa M, Kaneto H, Sasaki S, Imai K, Shinomura Y. Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids. World J Gastroenterol 2013; 19(11): 1718-1727
URL: https://www.wjgnet.com/1007-9327/full/v19/i11/1718.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i11.1718