Clinical features of gastroduodenal injury associated with long-term low-dose aspirin therapy

Table 1 Incidence of upper gastrointestinal events in low-dose aspirin users

Ref.	Subjects	GI event	Incidence rate
Yeomans et al[12]	187	Gastroduodenal	10.7%
		Gastroduodenal	63.1%
Ishikawa et al[13]	1657	Gastroduodenal	2.65 (95%CI: 2.56-2.74) per 1000 patient years
Niv et al[14]	46 asymptomatic	Gastroduodenal ulcer or erosion	47.83%
Taha et al[17]	200	Gastroduodenal ulcer	23.5%
Scheiman et al[18]	2426 high risk	Gastroduodenal ulcer	7.4%
Sugano et al[19]	235 with a history of ulcer	Gastroduodenal ulcer	31.7%
Serrano et al[9]	903	Upper GI bleeding	1.2 per 100 patient years
Sorensen et al[10]	27  694	Upper GI bleeding	2.6 (95%CI: 2.2-2.9)
Nema et al[15]	101	Gastroduodenal mucosal injury	61.4%
		Gastroduodenal ulcer	18.8%
Nema et al[16]	190	Gastroduodenal mucosal defects	48.4%

GI: Gastrointestinal.