Scolopendra subspinipes mutilans protected the cerulein-induced acute pancreatitis by inhibiting high-mobility group box protein-1

Figure 2 Effects of Scolopendra subspinipes mutilans pretreatment on the pancreatic weight/body weight ratio and the production of digestive enzymes such as serum amylase and serum lipase during cerulein-induced acute pancreatitis. Mice pretreated with Scolopendra subspinipes mutilans (SSM) (0.1, 0.5 or 1 g/kg) were challenged with intraperitoneal injections of cerulein (50 μg/kg). Mice were sacrificed 6 h after the last cerulein injection. Serum and pancreas were harvested and the pancreatic weight (PW)/body weight (BW) (A) and levels of digestive enzymes such as amylase (B) and lipase (C) were measured as indicated in the experimental protocol. Data are represented as mean ± SE (n = 6 in each group). The results were similar in 3 further experiments. ^aP < 0.05 vs control group, ^cP < 0.05 vs cerulein treatment alone. AP: Acute pancreatitis.