B7-H1 expression is associated with expansion of regulatory T cells in colorectal carcinoma

Figure 3 An elevated CD4⁺Foxp3⁺ and CD8⁺Foxp3⁺T cell amount observed in B7-H1^high colorectal carcinoma tissues. Mononuclear cells were harvested from fresh tumor tissues (A) and the peripheral blood (B) of the same colorectal carcinoma patient. The percentage of the Foxp3⁺ T cells was determined by fluorescence-activated cell sorting analysis. A: The population of CD4⁺Foxp3⁺ and CD8⁺Foxp3⁺T cells was increased remarkably in B7-H1^high colorectal carcinoma (CRC) tissues compared with B7-H1^low CRC tissues; B: In peripheral blood, there was no significant diversity of regulatory T cells between the B7-H1low and B7-H1high CRC patients.