Low-dose steroid pretreatment ameliorates the transient impairment of liver regeneration

Figure 4 Immunohistochemistry for 5-bromo-2-deoxyuridine staining in the partial hepatectomy with dexamethasone pretreatment group (A-H) and partial hepatectomy after radiofrequency ablation with dexamethasone pretreatment group (I-P) at 1 d after the operations. Animals were pretreated with 0 mg/kg (A and I), 0.002 mg/kg (B and J), 0.02 mg/kg (C and K), 0.04 mg/kg (D and L), 0.2 mg/kg (E and M), 0.4 mg/kg (F and N), 1 mg/kg (G and O), or 2 mg/kg (H and P) dexamethasone. Q: The brown nuclei are positive for 5-bromo-2-deoxyuridine. The labeling indices were calculated from 20 fields in three different sections per treatment for five different animals; R: Serum tumor necrosis factor-α levels at 1 d after the operations. The horizontal axis presents each concentration of dexamethasone pretreatment. ^aP < 0.05 between groups. S-PH: Steroid pretreatment in the partial hepatectomy group; S-PHA: Steroid pretreatment in the partial hepatectomy after radiofrequency ablation group; LIs: Labeling indices.