Histotype-based prognostic classification of gastric cancer

Table 3 Survival analysis of 492 tumors (Varese + Pavia series) according to histotype and grade

					Cox survival analysis
	n (%)						P value
	Varese series	Joint series	Death rate	95% CI	HR1	95% CI	Univariate	With stage
Grade 1	44 (22)	132 (26.8)	2.54	1.80-3.57	1
HLR	38 (19)	82 (16.6)	3.67	2.50-5.39	1
WD tubular	2 (1)	13 (2.6)	0
Lg diff.desm	2 (1)	17 (3.5)	1.50	0.48-4.64	0.43	0.13-1.42	0.167	0.109
muconodular	2 (1)	20 (4.1)	1.67	0.63-4.44	0.51	0.18-1.46	0.211	0.271
Grade 2	142 (71)	307 (62.4)	15.97	13.96-18.28	4.91	3.40-7.11	< 0.001	< 0.001
Mucinous ord.	4 (2)	10 (2.0)	11.50	5.16-25.59	2.16	0.89-5.24	0.090a	0.987b
Cohesive ord.	95 (47.5)	196 (39.8)	15.28	12.89-18.11	3.43	2.25-5.23	< 0.001	0.001
Diffuse ord.	43 (21.5)	101 (20.6)	18.09	14.36-22.79	3.96	2.53-6.22	< 0.001	< 0.001
Grade 3	14 (7)	53 (10.8)	108.84	82.02-144.43	18.47	11.56-29.50	< 0.001c	< 0.001c
Mucinous Hg.	3 (1.5)	21 (4.3)	100.0	64.07-160.0	11.54	6.32-21.48	< 0.001	< 0.001
Anaplastic	11 (5.5)	32 (6.5)	120.0	80.01-170.0	14.11	8.17-24.39	< 0.001	< 0.001

¹For grades, based on grade 1; for histotypes, based on high lymphoid response (HLR) type.

^aP = 0.005 vs muconodular and P < 0.001 vs mucinous.

^bP = 0.037 vs muconodular and P < 0.001 vs mucinous.

^cP < 0.001 vs grade 2. Harrell’s c = 0.69 for the 3 grades and 0.71 for the 9 histotypes. CI: Confidence intervals; HR: Hazard ratio; WD: Well differentiated; diff.desm: Diffuse desmoplastic; ord.: Ordinary; Hg.: High-grade.