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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 7, 2012; 18(9): 882-888
Published online Mar 7, 2012. doi: 10.3748/wjg.v18.i9.882
Published online Mar 7, 2012. doi: 10.3748/wjg.v18.i9.882
AML | hPer3 gene | Hypermethylation |
Fragile X syndrome | Loss of FMR1/FMR2 function | Promoter methylation |
ATR-X syndrome | Loss of ATRX function | Hypomethylation of certain repeat and satellite sequences |
Immunodeficiency, centromeric region instability, and facial anomaly syndrome | DNMT3b mutation | Centromeric DNA hypomethylation |
Beckwith-Wiedeman syndrome | Disruption of the imprinted IGF2/CDKN1C loci on 11p15.5 | Loss of genomic imprinting |
Williams syndrome | Loss of WSTF function | Condensed chromatin structures |
Rubinstein-Taybi syndrome | Mutations in the gene encoding CREB -binding protein | Reduced histone H3 acetylation |
Prader-Willi syndrome | Disruption of the imprinted SNRF/SNRPN locus on 15q11–13 | Disruption of genomic imprinting |
Coffin-Lowry syndrome | Mutation in RSK genes | Disrupted chromatin remodeling via activation of CREB-binding protein |
- Citation: Li XQ, Guo YY, De W. DNA methylation and microRNAs in cancer. World J Gastroenterol 2012; 18(9): 882-888
- URL: https://www.wjgnet.com/1007-9327/full/v18/i9/882.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i9.882