Review
Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 7, 2012; 18(9): 882-888
Published online Mar 7, 2012. doi: 10.3748/wjg.v18.i9.882
Table 1 Methylation and diseases
AMLhPer3 geneHypermethylation
Fragile X syndromeLoss of FMR1/FMR2 functionPromoter methylation
ATR-X syndromeLoss of ATRX functionHypomethylation of certain repeat and satellite sequences
Immunodeficiency, centromeric region instability, and facial anomaly syndromeDNMT3b mutationCentromeric DNA hypomethylation
Beckwith-Wiedeman syndromeDisruption of the imprinted IGF2/CDKN1C loci on 11p15.5Loss of genomic imprinting
Williams syndromeLoss of WSTF functionCondensed chromatin structures
Rubinstein-Taybi syndromeMutations in the gene encoding CREB -binding proteinReduced histone H3 acetylation
Prader-Willi syndromeDisruption of the imprinted SNRF/SNRPN locus on 15q11–13Disruption of genomic imprinting
Coffin-Lowry syndromeMutation in RSK genesDisrupted chromatin remodeling via activation of CREB-binding protein