Antimicrobial management of intra-abdominal infections: Literature's guidelines

Table 3 Antimicrobial regimens recommended by the World Society of Emergency Surgery recommendations for hospital-acquired intra-abdominal infections

	Antimicrobial agents	Dosage
In stable, non-critical patients	Piperacillin	8 g LD then 16 g/d via continuous infusion or 4 every 6 h (4-h infusion time)
	+
	Tigecycline	100 mg LD then 50 mg every 12 h (2-h infusion time)
	+
	Fluconazole	600 mg LD then 400 mg every 24 h (2-h infusion time)
In critically ill patients	Piperacillin	8 g LD then 16 g/d via continuous infusion or 4 every 6 h (4-h infusion time)
	+
	Tigecycline	100 mg LD then 50 mg every 12 h (2-h infusion time)
	+
	Echinocandin
	Caspofungin	(loading dose of 70 mg, then 50 mg daily)
	Anidulafungin	(loading dose of 200 mg, then 100 mg daily)
	Micafungin	(100 mg daily)
	Meropenem	500 mg every 6 h (6-h infusion time)
	or
	Imipenem	500 mg every 4 h (3-h infusion time)
	or
	Doripenem	500 mg every 8 h (4-h infusion time)
	+
	Teicoplanin	1.6 g via continuous infusion or 400 mg every 6 h (4-h infusion time)
	+
	Echinocandin
	Caspofungin	(loading dose of 70 mg, then 50 mg daily)
	Anidulafungin	(loading dose of 200 mg, then 100 mg daily)
	Micafungin	(100 mg daily)

LD: Loading dose.