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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 28, 2012; 18(8): 814-820
Published online Feb 28, 2012. doi: 10.3748/wjg.v18.i8.814
Published online Feb 28, 2012. doi: 10.3748/wjg.v18.i8.814
Figure 2 DNA sequencing result showing the germline mutations of MSH2 gene identified in 4 Lynch syndrome patients.
A: Deleterious mutation, c.142G > T, which resulted in a nonsense mutation (Glu48Stop); B: Novel mutation, transversion mutation c.2005G > C, which resulted in a missense mutation (Gly669Arg); C: Splice-site mutation, c.2006-6T > C, which was adjacent to exon 13 of MSH2 gene; D: MLH1 promoter polymorphism, -93G > A (rs1800734).
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Citation: Zahary MN, Kaur G, Abu Hassan MR, Singh H, Naik VR, Ankathil R. Germline mutation analysis of
MLH1 andMSH2 in Malaysian Lynch syndrome patients. World J Gastroenterol 2012; 18(8): 814-820 - URL: https://www.wjgnet.com/1007-9327/full/v18/i8/814.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i8.814