Routine blood tests to predict liver fibrosis in chronic hepatitis C

Table 3 Correlation of histological fibrosis severity with the variables

	Bivariate Spearman’s rank correlation coefficient (95% CI)	P value
Age (yr)	0.232 (0.108-0.349)	< 0.001
AST (U/L)	0.188 (0.062-0.308)	0.004
ALT (U/L)	-0.028 (-0.155 to 0.100)	0.666
PT INR	0.337 (0.219-0.445)	< 0.001
PLT (× 103/μL)	-0.326 (-0.435 to -0.207)	< 0.001
Hb	-0.176 (-0.297 to -0.050)	0.005
WBC	-0.053 (-0.179 to 0.075)	0.404
Cr	-0.152 (-0.274 to -0.025)	0.02
FT4	-0.167 (-0.288 to -0.040)	0.014
TSH	0.065 (-0.063 to 0.191)	0.341
Bil(T)	0.135 (0.008-0.258)	0.04
AAR	0.341 (0.223-0.449)	< 0.001
APRI	0.322 (0.203-0.431)	< 0.001
FibroQ	0.444 (0.336-0.541)	< 0.001
FIB-4	0.429 (0.319-0.528)	< 0.001
CDS	0.185 (0.059-0.305)	0.004
API	0.360 (0.244-0.466)	< 0.001
Lok’s model	0.430 (0.320-0.528)	< 0.001
Pohl score	0.144 (0.017-0.267)	0.027

We used Fisher’s Z-transform to compute asymmetric confidence limits for the Spearman's rank correlation coefficients. Hb: Hemoglobin; Bil(T): Total bilirubin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; PLT: Posterolateral thoracotomy; PT-INR: Prothrombin time international normalized ratio; WBC: White blood cell; FT4: Free thyroxine; TSH: Thyroid stimulating hormone; AAR: AST/ALT ratio; APRI: AST-to-platelet ratio index; API: Age-platelet index; CDS: Cirrhosis discriminant score.