Differential effects of energy balance on experimentally-induced colitis

Figure 1 Plasma adipokines in SMAD3-/- mice after 20 wk on dietary treatment. A: Average plasma concentrations of leptin between diet groups prior to infection. Calorie restricted (CR) mice had significantly lower concentrations, whereas high fat (HF) mice had significantly higher concentrations of leptin compared to control (CON) mice (P < 0.01); B: Average plasma concentrations of adiponectin between diets prior to infection. Both CR and HF diet mice had significantly lower concentrations of adiponectin than mice on CON diet (P < 0.05). ^aP < 0.05 vs control; ^cP < 0.05 vs all other groups.