Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon

Figure 2 Chronic, fibrotizing phase of inflammatory bowel disease. The arrowed cytokeratin (CK) positive epithelial cells in a colonic crypt show α-smooth muscle actin (α-SMA) positivity. The initiation of the epithelial-to-mesenchymal transition is possible. (α-SMA: Red; CK: Green; nuclear counter-staining: Blue; fluorescence immunohistochemistry, taken by virtual microscope). DAPI: 4′,6′-diamidino-2-phenylindole hydrochloride.