Hyperpolarization-activated cyclic nucleotide-gated cation channel subtypes differentially modulate the excitability of murine small intestinal afferents

Figure 6 Immunostaining for hyperpolarization-activated cyclic nucleotide-gated cation isoforms in dorsal root ganglia and nodose ganglia sections. Hyperpolarization-activated cyclic nucleotide-gated cation channel 1 (HCN₁) immunoreactivity was not detectable in dorsal root ganglia (DRG) and nodose ganglia (NG) neurons. HCN₂ immunoreactivity was prominent in DRG (cell bodies and fibers) and was also present in some NG neurons and fibers. HCN₃ immunoreactivity was profuse in NG sections but was weaker in DRG sections. HCN₄ immunoreactivity was present in a minority of DRG neurons and was absent in NG.