Hyperpolarization-activated cyclic nucleotide-gated cation channel subtypes differentially modulate the excitability of murine small intestinal afferents

Figure 5 Effects of 8-Br-cAMP on the activation curves of I_h current in DiI-labeled dissociated dorsal root ganglia and nodose ganglia neurons. A and B: Overdraw of the I_h current traces elicited by a hyperpolarizing pulse (-120 mV) in control and in the presence of 8-Br-cAMP in DiI-labeled dissociated dorsal root ganglia (DRG) (A) and nodose neurons (B); C: Activation curves of cAMP-sensitive and cAMP-insensitive DiI-labeled DRG neurons before (black block symbols) and after treatment with 8-Br-cAMP (empty symbols); D: Activation curves of DiI-labeled nodose ganglia neurons before (black block triangle) and after treatment with 8-Br-cAMP (empty triangle). Data were expressed as mean ± SE.